Dipeptidyl peptidase 4 – An important digestive peptidase in Tenebrio molitor larvae
نویسندگان
چکیده
منابع مشابه
Dipeptidyl Peptidase-4 Inhibitor
In the United States, nearly 13% of adults aged 20 years and older have type 2 diabetes mellitus (T2DM), and its prevalence is still increasing (1,2). Microvascular and macrovascular abnormalities are common in patients with T2DM and are related to the severity and duration of hyperglycemia (3–5). Thus, treatment of hyperglycemia is an important way to prevent or delay diabetic vascular complic...
متن کاملA digestive prolyl carboxypeptidase in Tenebrio molitor larvae.
Prolyl carboxypeptidase (PRCP) is a lysosomal proline specific serine peptidase that also plays a vital role in the regulation of physiological processes in mammals. In this report, we isolate and characterize the first PRCP in an insect. PRCP was purified from the anterior midgut of larvae of a stored product pest, Tenebrio molitor, using a three-step chromatography strategy, and it was determ...
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The spectrum of Tenebrio molitor larval digestive proteinases was studied in the context of the spatial organization of protein digestion in the midgut. The pH of midgut contents increased from 5.2-5.6 to 7.8-8.2 from the anterior to the posterior. This pH gradient was reflected in the pH optima of the total proteolytic activity, 5.2 in the anterior and 9.0 in the posterior midgut. When measure...
متن کاملPhospholipids of Tenebrio molitor larvae
Phospholipids of Tenebrio molitor larvae were separated on columns of DEAE -cellulose and silicic acidHyflo Super Cel. The major phosphatide components were identified by various analytical procedures. Phosphatidyl choline was demonstrated to be the predominant phospholipid with a high percentage of phosphatidyl ethanolamine. A small amount of inositolcontaining phosphatides were present. Phosp...
متن کاملAdipose Dipeptidyl Peptidase-4 and Obesity
OBJECTIVE To study expression of the recently identified adipokine dipeptidyl peptidase-4 (DPP4) in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) of patients with various BMIs and insulin sensitivities, as well as to assess circulating DPP4 in relation to obesity and insulin sensitivity. RESEARCH DESIGN AND METHODS DPP4 expression was measured in SAT and VAT from 196 sub...
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ژورنال
عنوان ژورنال: Insect Biochemistry and Molecular Biology
سال: 2016
ISSN: 0965-1748
DOI: 10.1016/j.ibmb.2016.07.003